- Expertise article
- Jeong et al., 2018
This study evaluated porcine reproductive and respiratory syndrome virus (PRRSV)-2 modiied live virus (MLV) vaccine against heterologous single and dual challenge of Korean PRRSV-1 and PRRSV-2. Pigs were administered PRRSV-2 MLV vaccine intramuscularly at 21 days of age and inoculated intranasally with both genotypes at 56 days of age. Vaccination of pigs with PRRSV-2 MLV vaccine resulted in reduction of viral loads of both PRRSV-1 and PRRSV-2 ater heterologous single and dual challenge with PRRSV-1 and PRRSV-2. In addition, pigs vaccinat- ed with PRRSV-2 MLV vaccine exhibited higher frequencies of PRRSV-1 and PRRSV-2 speciic interferon-γ secret- ing cells (IFN-γ-SC) and showed a signiicant reduction in lung lesions and PRRSV nucleic acid within the lung lesions ater single and dual challenge compared with unvaccinated challenged pigs. Taken together these results demonstrated that vaccination of pigs with PRRSV-2 is eicacious in protecting growing pigs from respiratory disease against heterologous single and dual PRRSV-1 and PRRSV-2 challenge.
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