- Top publications | February 2023
- Yanli Li et al.
PRRS is one of the major swine pathogens causing reproductive failure in sows.
Although modified-live virus (MLV) vaccines are available, vaccinated sows can be infected and cause transplacental infection. The present study investigated the role of cytotoxic lymphocytes, including cytotoxic T cells (CTL), NKT, and NK cells, from blood in preventing PRRSV-1 transplacental infection in vaccinated primiparous sows. The study data strongly suggest that cytotoxic t cell responses correlate with protection against PRRSV-1 transplacental infection, being executed by CD4 T cells (IFN-g related) and/or CD4/CD8a DN T cells (TNF-a related).